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All patients treated with tizanidine should have liver function tests performed at baseline, 1, 3 and 6 months, and periodically thereafter. You should not take ciprofloxacin if you are already taking tizanidine. Luvox CR Capsules and tizanidine should not be used together (see CONTRAINDICATIONS and PRECAUTIONS). Therapy with tizanidine should be administered cautiously in patients with or predisposed to hypotension. Prolonged pharmacologic effects of tizanidine may occur due to drug accumulation. Because of potential hepatotoxicity, therapy with tizanidine should be administered cautiously in patients with impaired hepatic function.
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